Cannabidiol: A Promising Drug for Neurodegenerative Disorders

Iuvone, T. , Esposito, G. , De Filippis, D. , Scuderi, C. and Steardo, L. (2009), Cannabidiol: A Promising Drug for Neurodegenerative Disorders?. CNS Neuroscience & Therapeutics, 15: 65-75. doi:10.1111/j.1755-5949.2008.00065.x

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The present review summarized a growing number of evidences, indicating an emerging role for CBD in the prevention and management of the main neurodegenerative disorders. CBD, in fact, resulted in being able to protect neuronal and nonneural cells against several detrimental insults, such as β‐amyloid or 6‐hydroxydopamine and glutamate [62, 70, 71], which are considered to be the basis of disorders such as AD and PD. The protective effects of CBD have been, moreover, evidenced in several animal models of neurodegeneration, and very interestingly, important clinical trials have confirmed the potential pharmacological activity of CBD in the management of clinical symptoms and the slow‐down of the progression of a variety of pathologies, including AD, MS, PD, and ASL.

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